October 6, 2025

10 Best Sinus Medicine of 2025

Last Updated - October 6, 2025

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Up to 39% off

1

9.9

Outstanding

GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

GenCare

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GenCare - Nasal Decongestant (10mg Tablets) Phenylephrine HCl (300 Tablets Per Bottle) | Value Pack Non Drowsy Sinus and Nasal Congestion Relief | Lower Sinus Pressure Due to Allergies or Illness

Why We Love It

ULTIMATE SINUS RELIEF - Experience maximum strength nasal decongestion and sinus pressure relief from indoor or outdoor allergies or common cold symptoms. 10 mg of Phenylephrine HCl helps alleviate pressure in your nose, sinus, ears, and throat.
BREATHE EASIER - Lowering sinus pressure and eliminating congestion can help you breathe better and deeper during the day or night. This over the counter decongestant can help with common symptoms like runny nose or blocked nasal passages.
NON DROWSY FORMULA - GenCare Nasal Decongestion can be taken any time of day including the morning or daytime. Many decongestant treatments are only suitable for nighttime use and are therefore limited for active adults and kids who need relief all day long.
BULK SAVINGS BOTTLE - Stop worrying about constant refills with our value savings 300 tablet family size bottle. This is the perfect size for families or people who suffer from chronic congestion due to allergies or seasonal illness.
100% SATISFACTION GUARANTEE - We know you and your family will love the ultimate convenience of our 300 count bulk savings bottle. That's why we back up each tamper proof bottle with our 100% Satisfaction Guarantee. Join thousands of nasal decongestion customers...Click Add-to-Cart Today

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Why We Love It

ULTIMATE SINUS RELIEF - Experience maximum strength nasal decongestion and sinus pressure relief from indoor or outdoor allergies or common cold symptoms. 10 mg of Phenylephrine HCl helps alleviate pressure in your nose, sinus, ears, and throat.
BREATHE EASIER - Lowering sinus pressure and eliminating congestion can help you breathe better and deeper during the day or night. This over the counter decongestant can help with common symptoms like runny nose or blocked nasal passages.
NON DROWSY FORMULA - GenCare Nasal Decongestion can be taken any time of day including the morning or daytime. Many decongestant treatments are only suitable for nighttime use and are therefore limited for active adults and kids who need relief all day long.
BULK SAVINGS BOTTLE - Stop worrying about constant refills with our value savings 300 tablet family size bottle. This is the perfect size for families or people who suffer from chronic congestion due to allergies or seasonal illness.
100% SATISFACTION GUARANTEE - We know you and your family will love the ultimate convenience of our 300 count bulk savings bottle. That's why we back up each tamper proof bottle with our 100% Satisfaction Guarantee. Join thousands of nasal decongestion customers...Click Add-to-Cart Today

2

9.5

Excellent

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

Mucinex

Mucinex Rapid Clear Maximum Strength Cold Medicine & Expectorant, Fever, Pain, Headache, & Excess Mucus Relief with Acetaminophen & Guaifenesin, Rapid Release Caplets for Adults, 20 Count

Main Highlights

PAIN RELIEF: Acetaminophen helps reduce fever and helps relieve body aches and headache associated with cold and flu
EXCESS MUCUS RELIEF: The expectorant, Guaifenesin, provides effective excess mucus relief by thinning and loosening bothersome mucus in your chest, helping to clear chest congestion
COLD MEDICINE: Mucinex Rapid Clear Pain, Headache, & Mucus Congestion is a trusted cold medicine for adults, offering comprehensive relief from cold and flu symptoms including fever, body pain, sore throat, headache, and excess mucus
HEADACHE RELIEF: Helps relieve headaches including those associated with cold and flu
EXPECTORANT: Contains Guaifenesin, an expectorant that aids in thinning and loosening mucus for more productive coughs and chest congestion relief
RAPID RELEASE CAPLETS: Mucinex Rapid Clear caplets start working fast
MAXIMUM STRENGTH & NON-DROWSY: With Mucinex Rapid Clear, it's not "power through with a pounding headache" seasonIt's comeback season

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Main Highlights

PAIN RELIEF: Acetaminophen helps reduce fever and helps relieve body aches and headache associated with cold and flu
EXCESS MUCUS RELIEF: The expectorant, Guaifenesin, provides effective excess mucus relief by thinning and loosening bothersome mucus in your chest, helping to clear chest congestion
COLD MEDICINE: Mucinex Rapid Clear Pain, Headache, & Mucus Congestion is a trusted cold medicine for adults, offering comprehensive relief from cold and flu symptoms including fever, body pain, sore throat, headache, and excess mucus
HEADACHE RELIEF: Helps relieve headaches including those associated with cold and flu
EXPECTORANT: Contains Guaifenesin, an expectorant that aids in thinning and loosening mucus for more productive coughs and chest congestion relief
RAPID RELEASE CAPLETS: Mucinex Rapid Clear caplets start working fast
MAXIMUM STRENGTH & NON-DROWSY: With Mucinex Rapid Clear, it's not "power through with a pounding headache" seasonIt's comeback season

3

9.5

Excellent

Sudafed PE Sinus Congestion Relief Tablets, Maximum Strength, Non-Drowsy 10 mg Phenylephrine HCI Decongestant for Sinus Pressure & Nasal Congestion Relief, Due to Cold or Allergies, 36 ct

Sudafed

Sudafed PE Sinus Congestion Relief Tablets, Maximum Strength, Non-Drowsy 10 mg Phenylephrine HCI Decongestant for Sinus Pressure & Nasal Congestion Relief, Due to Cold or Allergies, 36 ct

Main Highlights

SINUS PRESSURE & CONGESTION RELIEF: 36-count package of Sudafed PE Sinus Congestion, a maximum strength non-drowsy decongestant tablet for fast and powerful relief of sinus pressure and sinus and nasal congestion
NON-DROWSY COLD & SINUS MEDICINE: Sudafed sinus congestion and cold relief medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold for non-drowsy symptom relief
POWERFUL PHENYLEPHRINE FORMULA: Each sinus pressure relief tablet contains 10 mg of phenylephrine HCI, a nasal decongestant that provides fast and powerful symptom relief. The decongestant helps reduces nasal swelling to help you breathe easier
HOW TO USE: Sudafed PE sinus congestion tablets can be used by adults and children ages 12 and up. Take one nasal decongestant tablet every four hours; do not exceed six tablets within a 24 hour time period
FSA HSA APPROVED PRODUCT: Sinus pressure due to cold and allergies medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure is HSA & FSA eligible. Product eligibility may vary by plan

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Main Highlights

SINUS PRESSURE & CONGESTION RELIEF: 36-count package of Sudafed PE Sinus Congestion, a maximum strength non-drowsy decongestant tablet for fast and powerful relief of sinus pressure and sinus and nasal congestion
NON-DROWSY COLD & SINUS MEDICINE: Sudafed sinus congestion and cold relief medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold for non-drowsy symptom relief
POWERFUL PHENYLEPHRINE FORMULA: Each sinus pressure relief tablet contains 10 mg of phenylephrine HCI, a nasal decongestant that provides fast and powerful symptom relief. The decongestant helps reduces nasal swelling to help you breathe easier
HOW TO USE: Sudafed PE sinus congestion tablets can be used by adults and children ages 12 and up. Take one nasal decongestant tablet every four hours; do not exceed six tablets within a 24 hour time period
FSA HSA APPROVED PRODUCT: Sinus pressure due to cold and allergies medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure is HSA & FSA eligible. Product eligibility may vary by plan

4

9.2

Excellent

Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 20 Coated Tablets

Advil

Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl - 20 Coated Tablets

Main Highlights

One package of 20 coated tablets of Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl
Advil ibuprofen 200mg pain medicine for adults temporarily relieves fever, minor body aches and headache
Phenylephrine HCl 10 mg tablets provide sinus pressure relief, nasal congestion relief and nasal swelling relief
Coated tablets are easily portable, so you can have Advil congestion relief ready whenever you need it
Sinus congestion medicine for adults and children 12 years and older - the perfect addition to your college dorm room essentials
Take one of these sinus decongestant tablets every 4 hours as needed for symptoms
HSA and FSA eligible product

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Main Highlights

One package of 20 coated tablets of Advil Sinus Congestion and Pain, Sinus Relief Medicine, Pain Reliever and Fever Reducer with Ibuprofen and Phenylephrine HCl
Advil ibuprofen 200mg pain medicine for adults temporarily relieves fever, minor body aches and headache
Phenylephrine HCl 10 mg tablets provide sinus pressure relief, nasal congestion relief and nasal swelling relief
Coated tablets are easily portable, so you can have Advil congestion relief ready whenever you need it
Sinus congestion medicine for adults and children 12 years and older - the perfect addition to your college dorm room essentials
Take one of these sinus decongestant tablets every 4 hours as needed for symptoms
HSA and FSA eligible product

5

9.0

Excellent

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

Sudafed

Sudafed PE Sinus Pressure + Pain Relief Tablets, Maximum Strength, Non-Drowsy, OTC Sinus Relief Medicine with Acetaminophen Pain Reliever & Phenylephrine HCl Nasal Decongestant, 24 ct

Main Highlights

DECONGESTANT & PAIN RELIEF: 24-count package of Sudafed PE Sinus Pressure and Pain maximum strength non-drowsy decongestant tablets for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion
NON-DROWSY COLD & SINUS MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold, plus, helps relieve sinus pressure and sinus headaches
PHENYLEPHRINE & ACETAMINOPHEN: Each sinus congestion and pressure relief tablet contains 5 mg of phenylephrine HCI, a nasal decongestant that provides non-drowsy relief, plus, 325 mg of acetaminophen, a pain and fever reducer
HOW TO USE: Sudafed PE sinus pressure and pain relief congestion relief tablets can be used by adults and children ages 12 and up. Take two tablets every four hours; do not exceed 10 tablets within a 24 hour time period
FSA HSA APPROVED PRODUCT: Sinus congestion relief and pain medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure + Pain is HSA & FSA eligible. Product eligibility may vary by plan

View Deal on:

Main Highlights

DECONGESTANT & PAIN RELIEF: 24-count package of Sudafed PE Sinus Pressure and Pain maximum strength non-drowsy decongestant tablets for fast and powerful relief of sinus congestion, sinus pressure, and nasal congestion
NON-DROWSY COLD & SINUS MEDICINE: Sudafed sinus and pain medication helps to temporarily relieve nasal congestion associated with hay fever, upper respiratory allergies and the common cold, plus, helps relieve sinus pressure and sinus headaches
PHENYLEPHRINE & ACETAMINOPHEN: Each sinus congestion and pressure relief tablet contains 5 mg of phenylephrine HCI, a nasal decongestant that provides non-drowsy relief, plus, 325 mg of acetaminophen, a pain and fever reducer
HOW TO USE: Sudafed PE sinus pressure and pain relief congestion relief tablets can be used by adults and children ages 12 and up. Take two tablets every four hours; do not exceed 10 tablets within a 24 hour time period
FSA HSA APPROVED PRODUCT: Sinus congestion relief and pain medicine from Sudafed, the #1 pharmacist recommended brand among oral OTC decongestants. Sudafed PE Sinus Pressure + Pain is HSA & FSA eligible. Product eligibility may vary by plan

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6

8.8

Very Good

Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps

Vicks

Vicks Sinex SEVERE, All-In-One Sinus + Mucus Relief, Non-Drowsy, Loosens Mucus, Maximum Strength Relief of Pain, Pressure, Congestion, & Headache Relief, 24 LiquiCaps

Main Highlights

Experience fast, powerful relief from nasal congestion, sinus pressure, sinus headache, sinus pain, chest congestion and mucus!
Best suited to treat sinus symptoms caused by the common cold, hay fever, or other upper respiratory allergies because it thins and loosens mucus, reduces pressure in the sinuses, and relieves sinus pain!
The powerful, non-drowsy nasal decongestant medicine, expectorant, and pain reliever help to provide all in one relief for your sinus symptoms!
HSA and FSA eligible, Check with your provider for more details
This product is not formulated with an antihistimine allergy medicine and is not intended to treat runny nose, itchy & watery eyes, or sneezing

View Deal on:

Main Highlights

Experience fast, powerful relief from nasal congestion, sinus pressure, sinus headache, sinus pain, chest congestion and mucus!
Best suited to treat sinus symptoms caused by the common cold, hay fever, or other upper respiratory allergies because it thins and loosens mucus, reduces pressure in the sinuses, and relieves sinus pain!
The powerful, non-drowsy nasal decongestant medicine, expectorant, and pain reliever help to provide all in one relief for your sinus symptoms!
HSA and FSA eligible, Check with your provider for more details
This product is not formulated with an antihistimine allergy medicine and is not intended to treat runny nose, itchy & watery eyes, or sneezing

7

8.6

Very Good

Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

Tylenol

Tylenol Sinus Severe Daytime Cold & Flu Relief Medicine Caplets, Non-Drowsy Pain Reliever, Fever Reducer Expectorant & Decongestant, Acetaminophen, Guaifenesin & Phenylephrine HCl, 24 ct

Main Highlights

24-count of Tylenol Sinus Severe Daytime Medicine Caplets for non-drowsy relief of symptoms due to the common cold, flu, hay fever or other respiratory allergies such as mucus and sinus congestion
Pain reliever, fever reducer, decongestant and expectorant medicine temporarily relieves minor aches and pains as well as symptoms of chest congestion, nasal congestion, sinus headache and pressure
Each caplet contains 325 milligrams of acetaminophen to reduce fever and pain; 5 milligrams of nasal decongestant phenylephrine HCl to help clear nasal passages; and 200 milligrams of the expectorant guaifenesin to help make coughs more productive
The non-drowsy formula of this sinus decongestant medicine provides effective daytime symptom relief by promoting sinus drainage, decongesting sinus openings and passages, and thinning bronchial secretions to help make coughs more productive
From the #1 doctor recommended pain relief brand, these severe sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief

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Main Highlights

24-count of Tylenol Sinus Severe Daytime Medicine Caplets for non-drowsy relief of symptoms due to the common cold, flu, hay fever or other respiratory allergies such as mucus and sinus congestion
Pain reliever, fever reducer, decongestant and expectorant medicine temporarily relieves minor aches and pains as well as symptoms of chest congestion, nasal congestion, sinus headache and pressure
Each caplet contains 325 milligrams of acetaminophen to reduce fever and pain; 5 milligrams of nasal decongestant phenylephrine HCl to help clear nasal passages; and 200 milligrams of the expectorant guaifenesin to help make coughs more productive
The non-drowsy formula of this sinus decongestant medicine provides effective daytime symptom relief by promoting sinus drainage, decongesting sinus openings and passages, and thinning bronchial secretions to help make coughs more productive
From the #1 doctor recommended pain relief brand, these severe sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief

8

8.3

Very Good

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

Tylenol

Tylenol Sinus + Headache Daytime Non-Drowsy Relief Caplets, Acetaminophen 325mg, Nasal Decongestant for Sinus Pressure, Headache & Nasal Congestion Relief, 24 ct

Main Highlights

24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies
Pain reliever and nasal decongestant formulated to temporarily reduce fever and relieve symptoms of nasal congestion, sinus headache and pressure
Each sinus relief caplet contains 325 milligrams of acetaminophen to temporarily relieve pain and reduce fever as well as 5 milligrams of phenylephrine HCl, a nasal decongestant to help clear nasal passages
The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage and helping to decongest sinus openings and passages
From the #1 doctor recommended pain relief brand, these daytime headache and sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief

View Deal on:

Main Highlights

24-count box of Tylenol Sinus + Headache Daytime Caplets for non-drowsy sinus symptom and headache pain relief due to the common cold, hay fever or other respiratory allergies
Pain reliever and nasal decongestant formulated to temporarily reduce fever and relieve symptoms of nasal congestion, sinus headache and pressure
Each sinus relief caplet contains 325 milligrams of acetaminophen to temporarily relieve pain and reduce fever as well as 5 milligrams of phenylephrine HCl, a nasal decongestant to help clear nasal passages
The non-drowsy formula of this sinus medicine provides effective daytime symptom relief by promoting sinus drainage and helping to decongest sinus openings and passages
From the #1 doctor recommended pain relief brand, these daytime headache and sinus relief caplets are suitable for adults and children ages 12 years and older for powerful daytime cold symptom relief

9

8.1

Very Good

Vicks Sinex SEVERE LiquiCaps, All-In-One Sinus Relief, Non-Drowsy, Nasal Decongestant, Maximum Strength Relief of Sinus Headache, Pain, Pressure, & Congestion, 24 LiquiCaps

Vicks

Vicks Sinex SEVERE LiquiCaps, All-In-One Sinus Relief, Non-Drowsy, Nasal Decongestant, Maximum Strength Relief of Sinus Headache, Pain, Pressure, & Congestion, 24 LiquiCaps

Main Highlights

Experience fast, powerful relief from nasal congestion, sinus pressure, sinus headache, and sinus pain!
Best suited to treat sinus symptoms caused by the common cold, hay fever, or other upper respiratory allergies because it reduces pressure in the sinuses and relieves sinus pain!
The powerful, non-drowsy nasal decongestant medicine and pain reliever help to provide all in one relief for your sinus symptoms!
HSA and FSA eligible, Check with your provider for more details
This product is not formulated with an antihistimine allergy medicine and is not intended to treat runny nose, itchy & watery eyes, or sneezing

View Deal on:

Main Highlights

Experience fast, powerful relief from nasal congestion, sinus pressure, sinus headache, and sinus pain!
Best suited to treat sinus symptoms caused by the common cold, hay fever, or other upper respiratory allergies because it reduces pressure in the sinuses and relieves sinus pain!
The powerful, non-drowsy nasal decongestant medicine and pain reliever help to provide all in one relief for your sinus symptoms!
HSA and FSA eligible, Check with your provider for more details
This product is not formulated with an antihistimine allergy medicine and is not intended to treat runny nose, itchy & watery eyes, or sneezing